ÓлúºÏ³É¼°Éè¼ÆORGANIC SYNTHESIS & DESIGN

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Chapter 1Introduction to Designing Organic Synthesis001
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Designing Organic Synthesis: General Issues001
1.2ÓлúºÏ³É»ù±¾Ô­Àí
The Principles of Synthetic Organic Chemistry007
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References013
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Part ¢ñFormation of Molecular Skeleton
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Chapter 2Carbon-Carbon Bonds Formation: Nucleophiles016
2.1Óлú½ðÊô»¯ºÏÎï
Organometallic Compounds016
2.2Îȶ¨µÄ̼¸ºÀë×Ó
Stabilized Carbanions041
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Reactions of Enolates and Related Nucleophiles with Carbonyl Compounds059
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References072
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Chapter 3Carbon-Carbon Bonds Formation: Carbocations074
3.1·¼ÌþÇ×µçÈ¡´ú
Electrophilic Aromatic Substitution074
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Self-Condensation of Alkenes086
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Cationic Rearrangements087
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References091
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Chapter 4Carbon-Carbon Bonds Formation: Free Radicals093
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Formation,Structure and Stabilities of Carbon Free Radicals093
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Types of Free Radical Reactions095
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Reactions of Free Radicals098
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References109
5̼»·ºÍÔÓ»·µÄÐγÉ
Chapter 5Formation of Carbocycles and Heterocycles110
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Formation of Carbocycles110
5.2ÔÓ»·µÄÐγÉ
Formation of Heterocycles129
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Ring Opening134
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References136
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Part ¢òMolecular Skeleton Modification
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Chapter 6Functional Group Interconversion138
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Introduction and Transformation of Functional Groups138
6.2¹ÙÄÜÍÅ»¥»»
Interconversion of Functional Groups149
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References156
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Chapter 7Protection and Deprotection of Functional Groups157
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Hydroxy-Protecting Groups158
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Carbonyl-Protecting Groups167
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Diol-Protecting Groups170
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Amino-Protecting Groups171
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Carboxy-Protecting Groups175
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Phosphate-Protecting Groups177
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Carbon Hydrogen-Protecting Groups178
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References180
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Part ¢óDesigning Organic Synthesis
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Chapter 8Retrosynthetic Analysis Strategy182
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Introduction to Retrosynthetic Analysis182
8.2ÄæºÏ³É·ÖÎöÕ½ÂÔ
Strategy in Retrosynthesis191
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References201
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Chapter 9Retrosynthetic Analysis of the Organic Compounds203
9.1µ¥¹ÙÄÜÍÅ»¯ºÏÎïÄæºÏ³É·ÖÎö
Retrosynthetic Analysis of the Compounds with One Functional Group203
9.2Ë«¹ÙÄÜÍÅ»¯ºÏÎïÄæºÏ³É·ÖÎö
Retrosynthetic Analysis with Participation of Two Functional Groups227
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References268
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Part ¢ôOrganic Synthesis Techniques
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Chapter 10Specific Synthetic Methods and Techniques272
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Multicomponent Reactions272
10.2ƽÐкϳÉÓë×éºÏ»¯Ñ§
Parallel Synthesis and Combinatorial Chemistry275
10.3ÓлúºÏ³ÉÖеĻúе»¯Ñ§
Mechanochemistry in Organic Synthesis277
10.4΢²¨·øÉä´Ù½øµÄÓлúºÏ³É
Organic Synthesis Promoted by Microwave Radiation278
10.5Àë×ÓÒºÌåÖеĺϳÉ
Syntheses in Ionic Liquids280
10.6ChemPUÖл¯Ñ§ºÏ³ÉÎÄÏ×Êý¾Ý¿âµÄÊý×Ö»¯ºÍÑéÖ¤
Digitization and Validation of a Chemical Synthesis Literature
Database in the ChemPU282
10.7ÉúÎï·Ö×ÓÏÖ´ú×Ô¶¯»¯ºÏ³É
Modern Automated Biomolecule Synthesis283
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References293