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The Biological Function and Molecular Mechanism of Ampelopsin and Exercise Mimetics in Chronic DiseasesContentsChapter 1Pharmacological potential of ampelopsin in Rattan tea1
Chapter 2Ampelopsin reduces endotoxic inflammation via repressing ROSª²mediated
activation of PI3K/Akt/NFª²κB signaling pathways8
Chapter 3Natural products for cancer prevention associated with Nrf2ª²ARE pathway23
Chapter 4Antiª²tumor effect31
4.1Potential molecular targets of ampelopsin in prevention and treatment of
cancers31
4.2Nutraceutical or pharmacological potential of Moringa oleifera Lam.39
4.3Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through
extrinsic and intrinsic pathways£ºinvolvement of p38 and ERK48
Chapter 5Neuroprotective effect59
5.1Ampelopsin inhibits H2O2ª²induced apoptosis by ERK and Akt signaling
pathways and upª²regulation of heme oxygenaseª²159
5.2Ampelopsin attenuates 6ª²OHDAª²induced neurotoxicity by regulating
GSKª²3β/NRF2/ARE signaling67
Chapter 6Autophagy and brain aging77
6.1Autophagy as the modulator of neuronal homeostasis and neurodegenerative disorders77
6.2Resveratrol as a natural autophagy regulator for prevention and treatment of Alzheimer’s disease80
6.3Ampelopsin attenuates brain aging of Dª²galª²induced rats through miRª²34aª²mediated SIRT1/mTOR signaling pathway89
6.4Swimming attenuates Dª²galactoseª²induced brain aging via suppressing miRª²34aª²mediated autophagy impairment and abnormal mitochondrial dynamics101
6.5Voluntary wheel running exercise suppresses brain aging of rats through activating miRª²130aª²mediated autophagy112
Chapter 7Sarcopenia123
7.1Research progress of sarcopenia123
7.2MicroRNAª²regulated proinflammatory cytokines in sarcopenia127
7.3Ampelopsin attenuates Dª²galª²induced oxidative stressª²related skeletal muscle atrophy through activating AMPK/SIRT1/PGCª²1α signaling cascade135
7.4Role and regulation of autophagy in mass maintenance of skeletal muscle147
Acknowledgement155
References156