Early-stage Lung Cancer

Early-stage Lung Cancer ÄÚÈݼò½é

At the time when low-dose computed tomography (CT) began to prevail over con- ventional radiography for lung cancer screening, the detection of subcentimeter pul-monary nodules began to increase dramatically. In this context, this book discussesmajor issues and advancements in the diagnosis and treatment of incidentallydetected, subcentimeter lung cancer (SLC). Dr. Guozhen Zhang, distinguished pro-fessor in radiology, proposed the "EAST" principle for the management of SLCs:Early detection, Accurate diagnosis, minimally invasive Surgery, and Teamwork forprecise biopsy. The EAST principle is thoroughly expanded upon throughout thebook. In Part I, experts from pathology and radiology comprehensively review thestate-of-the-art advancements in the screening and evaluation of SLCs, and thecross-sectional anatomy of the lung and post-processing techniques of CT imagingare updated. Part II focuses on the imaging features, differential diagnosis, andradiologic-pathologic correlations of SLCs in the categories of pGGN, mGGN, andsolid nodules, in compliance with the Guidelines on Lung Cancer Screening fromthe National Comprehensive Cancer Network (NCCN). Most importantly, the char acteristic CT sign for SLC diagnosis and differentiation, the CT angiogram of tumorangiogenesis (CTA-TA sign), or the "neo-vessel mobilization and intercommunica-tion" phenomenon-discovered and coined by Dr. Zhang-is extensively discussed.Part III briefly introduces the therapeutic management strategies for SLCs, includ-ing surgical and nonsurgical approaches, e.g., stereotactic ablative radiation therapy(SABR) and radiofrequency ablation (RFA). Finally, to highlight the applicabilityof subjects addressed in the previous chapters, authors have meticulously prepared50 clinical cases of benign and malignant pulmonary nodules with in-depth discus-sion and experts' comments for a self-test for readers, with the goal of furtheringunderstanding of the imaging and the management strategies for SLCs.